Post-doctoral researcher

Company Description

The University Health Network, where above all else the needs of patients come first , encompasses Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute and the Michener Institute of Education.

The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education.

With a long tradition of ground breaking firsts and a purpose of Transforming lives and communities through excellence in care, discovery and learning , the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers.

UHN is a caring, creative place where amazing people are amazing the world.

Job Description

Union : Non-Union

Site : Toronto Western Hospital-UHN

Department : Krembil Research Institute

Reports to : Dr. Martin Ingelsson

Work Model : On-Site

Grade : V0 : 90

Hours :

Salary : Staring at $51, annually

Shifts : Monday to Friday

Status : Temporary full-time (1-2 years)

Closing Date : May 31, 2024

Position Summary

The Ingelsson Lab is seeking a highly motivated and skilled Postdoctoral Researcher to contribute to cutting-edge research on the molecular aspects of Alzheimer’s disease, Parkinson’s disease, and other brain disorders associated with the accumulation of tau and alpha-synuclein.

The projects will mainly entail the generation and evaluation of monoclonal antibodies against these proteins.

Duties

The applicant will use the hybridoma technique on laboratory mice to generate monoclonal antibodies that can selectively recognize pathogenic variants of tau and alpha-synuclein.

In addition, the applicant will make use of cell biological and histopathological techniques to evaluate the immunotherapeutic effects of the antibodies ex vivo.

Passive immunotherapy and vector-mediated expression of monoclonal antibodies will be explored as preventive and therapeutic strategies for the respective disorders.

Qualifications

• A completed in biomedical science or biochemistry.
• A demonstrated track record of publications in indexed journals.
• Proficiency in basic laboratory techniques including immunohistochemistry, western blot, cell culture and ELISA.
• Previous experience with animal models and genetically modified mice.
• Excellent communication skills with the ability to collaborate effectively in a research environment.
• Strong organizational, time management, and recordkeeping skills.
• A proven ability to deliver high-quality work and maintain confidentiality.
• A capacity to work under the pressure of deadlines and find solutions to meet timelines.

Moreover, previous experience with antibody generation and protein engineering is meritorious.

The application should contain a cover letter (maximum 1 page) describing the applicant’s research interests, an updated CV with a list of publications, copies of diplomas and certificates of higher academic degrees as well as contact details (name, e-mail, phone number) of two referees.

Selection of candidates is based on qualifications, research experience, and personal suitability.

Additional Information

Why join UHN?

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks.

It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP )
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including : travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

All UHN Employees are required to be fully vaccinated with a COVID-19 vaccine series, approved by Health Canada or the World Health Organization, as a condition of hire.

Proof of COVID-19 vaccination will be required. Should you be the successful candidate, you will be required to comply with UHN’s mandatory Vaccination Policy that is in effect.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process.

Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.