Research Associate - Pouladi Lab

Job Title

Research Associate - Pouladi Lab

Job Category

Faculty Non Bargaining

Job Family Group

Academic

Department

Pouladi Laboratory | Department of Medical Genetics | Faculty of Medicine (Mahmoud Pouladi)

Job End Date

March 31, 2028

Posting End Date

December 12, 2026

Note:Applications will be accepted until 11:59 PM on the Posting End Date.

The expected pay (or pay range) for this position is between $76,128 - $90,000 per annum.

At UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research, innovation, and learning for all faculty, staff and students. Our commitment to employment equity helps achieve inclusion and fairness, brings rich diversity to UBC as a workplace, and creates the necessary conditions for a rewarding career.

The UBC Department of Medical Genetics seeks to be an inspiring and productive community of scholars; an outstanding provider of knowledge, technical expertise, and compassionate care for our patients; contributors to the scientific advance of our discipline; and a credible and respected source of information and advice to society at large. While focusing on areas of genetic medicine that we deem to be particularly important, we view diversity of approach and techniques to be an essential strength of our Department.

We acknowledge that the University of British Columbia Faculty of Medicine and its distributed programs, which include four university academic campuses, are located on traditional, ancestral and unceded territories of Indigenous peoples around the province.

The Department of Medical Genetics at The University of British Columbia (UBC) invites applications for a fixed-term full-time Research Associate.

Reporting to Dr. Mahmoud Pouladi, the successful candidate will hold an MD/PhD in Anatomy, Histology, or Pathology with a focus on neurobiology and 5+ years of postdoctoral experience and have:

• At least 10 years’ experience in laboratory research involving mouse models.
• Expertise in histology such as immunofluorescence staining, immunohistochemistry, in situ hybridisation (ISH) labelling, transmission electron microscopy (TEM), Golgi staining, dye tracing for anatomical brain connectivity mapping, whole brain 3D structure staining, clearing and imaging.
• Animal husbandry and related skills such as weaning, tailing, mouse behaviour testing, perfusions, tissue microdissection, in vivo delivery in the nervous system, in utero electroporation, and stereotaxic injections.
• Expertise in molecular biology techniques such as Western blotting, PCR, quantitative PCR, molecular cloning, Co-IP, and ChIP/CLIP.
• Expertise with ex vivo / in vitro cell culture techniques such as organotypic brain slice culture, brain tissue transplantation, primary cell culture, cell line culture, transfections, and lentivirus infection.
• Experience working with human pluripotent stem cells and their neural differentiation.
• Experience using genome editing using CRISPR/Cas9 in immortalized and human pluripotent stem cell lines.

Responsibilities include:

• Development and analysis of novel mouse and human pluripotent stem cell models of genetic neurological disorders.
• Analysis of brain development defects in mouse models of genetic disorders.
• Preclinical therapeutic studies in human pluripotent stem cell and mouse disease models.
• Performing and/or supervising behavioral and histological analyses of novel mouse models of genetic neurological disorders to elucidate the pathophysiology behind the disease, including managing mouse lines and carrying out relevant procedures such as behavioural experiments, microinjection, tissue collection, various types of sectioning, and staining.
• Differentiation of human pluripotent stem cells into neural cell types and organoids.
• Maintenance, expansion, and analysis of cell line, brain slice, and primary neuron cultures.
• Perform CRISPR-Cas9 genome editing, lentivirus infection shRNA, and transfection to knockout, knockdown, or overexpress to regulate gene expression levels.
• Electrophysiological recording, such as multi-electrode array (MEA)

Benefits

Plan Group Number: 020605Member ID: your 7-digit UBC employee ID number, Need crisis counselling?, Call GreenShield Health at 1-866-424-0770 to chat with a counsellor., Disclaimer, The benefits information on this website is provided as a descriptive summary only. While the University has endeavored to accurately reflect its benefit programs, policies and plans, the information on this website does not create any contractual or other rights between the University and its faculty and staff members. To the extent that there are any conflicts or discrepancies between the benefits information on this website and the benefit plan documents (including group insurance contracts and benefit booklets) or any applicable collective agreement, employment agreement, or UBC policy, the benefit plan documents and collective agreement, employment agreement, or UBC policy will govern in all cases.