Associate Scientist, In Vivo Pharmacology

Company Description
Zymeworks is a publicly listed (NASDAQ:ZYME) clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

Why Work With Us

Nothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we care about each other as well as the patients we serve. We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

Zymeworks is proudly headquartered in our brand new, net-zero facility located in the vibrant Main St biotech hub of Vancouver, BC, with operations in Bellevue, WA, Dublin, Ireland, Singapore and the Bay Area.

Work Requirement

This role will be based out of our Vancouver location and is full time onsite.

Key Responsibiliies

• Oversees all aspects of designing, planning, coordinating, and analyzing in vivo immuno-oncology efficacy and PK/PD experiments in collaboration with project team members.
• Manages studies with both internal counterparts and external contract research organizations.
• Supports animal research associates with the handling of mice (awake and/or under gaseous anesthetic, or after euthanasia), including subcutaneous, intraperitoneal and intravenous injections, tumor measurements, blood and tissue collection, and health monitoring.
• Performs mouse study-related administrative tasks including regulatory documentation and protocol updates.
• Organizes and performs the pharmacodynamic evaluation of immune cell function using flow cytometry, histology and MSD assays.
• Evaluates emerging technologies, develops new in vivo models, and establishes standard protocols and best practices.
• Provides leadership, mentorship, and scientific/technical guidance to junior staff.
• Summarizes and presents results to supervisor in a logical manner, verbally and in written reports or presentations. Must present data to project team meetings.
• Analyzes data using software including Excel, GraphPad Prism, FlowJo and authors electronic lab notebook entries suitable for IND enabling documentation.
• Conducts all activities in accordance with scientific standards, Canadian Council on Animal Care (CCAC) and OH&S regulations and established policies and practices.
• Actively works to foster an environment of effective and collaborative working relationships amongst employees, management, and external partners.

Education and Experience

• PhD in immunology, pharmacology, cancer biology, or a related scientific discipline with a minimum of 3 years experience working with rodents or a BSc and minimum 5 years of related experience.

Skills and Abilities

• Expertise in running xenograft, syngeneic, or humanized mouse tumor models (PBMC and/or CD34). Understanding of immune cell function in treatment and disease is required.
• Proficient in animal handling, dosing (SC, IP, IV) and collection of blood and tumor samples. Ability to consistently perform tail vein injections is required.
• Demonstrated understanding of in vivo cancer models, therapeutic mechanisms of actions, relationship of PK to therapeutic activity; demonstrated experience with antibody-based therapeutics is an asset.
• Experience with immune cell isolation and flow cytometry
• Excellent organizational skills to manage multifaceted studies in a fast-paced environment and meet deadlines within projected budgets.
• Experience working with contract research organizations for designing, coordinating, and carrying out large scale in vivo studies and summarizing findings to project teams.
• Proven interpersonal skills with the ability to work collaboratively as a member of a cross-functional scientific project team.

Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. We regularly benchmark our compensation against leading biotechnology companies in our geographies.

The Canadian base salary range for this full time position is $86, - $, + bonus + equity + benefits. Our salary ranges are determined by role, level, and location.

The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all Canadian locations. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate’s location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience).

Please note that the compensation details listed in role postings reflect the base salary only, and do not include bonus, equity, or benefits.

Our team enjoys:

• Industry leading vacation and paid time off
• Excellent health and wellness benefits
• Zymelife health and wellness benefits
• Paid time off to volunteer in your community
• Matching RRSP / K program
• Employee Share Purchase Program
• Employee Equity Program

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.