Upstream Processing Technician

Upstream Processing (USP) Technician

Our client is a leading national research and innovation organization advancing human health through cutting‑edge biotherapeutics and vaccines, offering the stability of the public sector with the innovation of a high‑tech biotech environment.

As an Upstream Processing (USP) Technician , you will support the manufacture of clinical biologics under current Good Manufacturing Practices (cGMP). You’ll work hands‑on with mammalian cell culture, bioreactors, and upstream operations to produce material for clinical studies in a highly regulated, team‑oriented environment.

Responsibilities

• Execute upstream manufacturing steps according to batch records and cGMP requirements
• Perform mammalian cell culture operations, including propagation, expansion, and clinical‑scale production in bioreactors
• Carry out in‑process testing using spectrophotometers, pH meters, metabolite analyzers, and related lab equipment
• Perform master cell bank manufacturing and filling under biosafety cabinet conditions
• Weigh, transfer, and mix chemicals and media components according to procedures
• Set up, install, and operate single‑use assemblies and related upstream processing equipment
• Conduct product filtration, centrifugation, and related upstream clarification steps
• Prepare and organise glassware and disposable assemblies for production runs
• Verify instrument calibration status prior to each production batch and document results
• Complete and review logbooks and other GMP documentation, performing corrections as required
• Support cleaning and autoclave activities in collaboration with production support teams
• Monitor stocks of common lab supplies and notify management of inventory needs
• Respond to emergency notifications following established procedures
• Participate in CAPA, Change Control, and Deviation reporting activities as needed

Requirements

What We Offer

Brunel manages the entire recruitment process, from submitting your resume to coordinating interviews, extending offers, and assisting with onboarding. We’ll get you started while you focus on the job.

About Us

Brunel has a reputation for working with some of the best in the business. Over 45 years, we’ve built a global network of clients and talented individuals working together through a range of professional services.

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