Senior Scientist – Directed Evolution & Protein Design, Large Molecule Discovery

Overview

Senior Scientist – Directed Evolution & Protein Design, Large Molecule Discovery at Amgen. Location: Amgen British Columbia site.

What You Will Do

Lead enzyme engineering efforts to discover novel therapeutics for rare and genetic diseases. Apply directed molecular evolution and rational design, including computational approaches. Develop quantitative structure–function relationships to enhance generative AI capabilities for enzyme and protein design. Implement computational design to predict and prevent immunogenicity of enzymes and other proteins. Contribute to the interface between protein design, enzyme engineering, target discovery, and experimental immunology.

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients.

Basic Qualifications

• Ph.D. in Biochemistry, Chemistry, Chemical and/or Biological Engineering, Biophysics or a related field with 1-3 years industrial or postdoc experience with strong publication record
• Experience in directed molecular evolution and high-throughput screening and characterization
• Experience in enzyme library design and in silico protein design
• Ability to work independently while also collaborating with cross-functional teams
• Strong organizational, interpersonal, and communication skills
• Self-driven, creative, and willingness to work on difficult and high impact problems
• Commitment to diversity and equity while creating a welcoming and inclusive work environment

Preferred Qualifications

• Understanding of immune biology and immunogenicity
• Strong background in structural biology and biophysics
• Application of AI/ML models to protein design and engineering

What You Can Expect Of Us

We support your professional and personal growth and well-being. From competitive benefits to a collaborative culture, we’ll support your journey every step of the way. The salary range for this position in Canada is CAD 117,814 – 140,059. Amgen is an Equal Opportunity employer. We will consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by law.

Additional Information

We provide reasonable accommodation to participate in the job application or interview process. Please contact us to request accommodation. Referrals increase your chances of interviewing. This role is located in Burnaby, BC; New Westminster, BC; and surrounding areas as applicable.