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Congruence Therapeutics
Senior Scientist, Computational ChemistryCongruence Therapeutics • Montreal, QC, Canada
Senior Scientist, Computational Chemistry

Senior Scientist, Computational Chemistry

Congruence Therapeutics • Montreal, QC, Canada
30+ days ago
Job type
  • Full-time
Job description

🔬 Senior Scientist, Computational Chemistry

Location: United States or Canada (Remote / Hybrid)

Compensation: base + bonus + equity


🚀 Build first-in class therapies by unlocking undruggable biology

Congruence Therapeutics is a clinical-stage biotech redefining small molecule drug discovery through advanced computational approaches. Our proprietary platform, Revenir™, captures protein conformational dynamics to identify novel allosteric and cryptic binding sites - enabling us to target diseases that have historically been out of reach.


We are advancing a pipeline across genetic diseases, including neurodegeneration and metabolic disorders, alongside partnerships with leading pharma companies.


🧠 The Opportunity

We’re hiring a Senior Scientist, Computational Chemistry to play a key role in shaping both our drug discovery programs and computational platform.

You will:

  • Own and drive computational strategy across programs
  • Influence molecular design decisions at scale
  • Work at the intersection of physics-based modeling and AI/ML
  • Mentor scientists and help scale a high-performing team

This is a high-visibility role with direct impact on pipeline progression and platform evolution.


🔍 What You’ll Do

  • Lead computational chemistry efforts across discovery programs (target assessment → hit identification → optimization)
  • Apply advanced methods including molecular dynamics, free energy calculations (FEP/TI), QSAR, and structure-based design
  • Partner with medicinal chemistry and AI teams to prioritize compounds and guide synthesis
  • Drive data-driven decision-making for potency, selectivity, and ADME/Tox optimization
  • Introduce and scale new computational methodologies and cheminformatics tools
  • Mentor team members and contribute to scientific leadership


🧬 What You Bring

  • PhD in computational chemistry, biophysics, or related field
  • ~10+ years of industry experience in small molecule drug discovery
  • Proven impact on advancing discovery programs
  • Expertise in:
  • Structure-based drug design & protein–ligand interactions
  • Molecular modeling (docking, FEP/TI, homology modeling)
  • Cheminformatics tools (RDKit, Schrödinger, MOE, OpenEye)
  • Experience with machine learning in molecular design (PyTorch, TensorFlow)
  • Strong programming skills (Python/R) and workflow automation
  • Experience working with cloud-based computational infrastructure
  • Demonstrated leadership and mentoring ability



🌟 What Sets You Apart

  • You think like a drug hunter—focused on delivering real therapies
  • You’re excited by novel computational approaches and platform building
  • You thrive in cross-functional, fast-moving environments
  • You bring ownership, scientific rigor, and curiosity


🌟 Why This Role Stands Out

  • Direct influence on both pipeline and platform
  • Exposure to multiple therapeutic areas and modalities
  • Strong integration of AI/ML + physics-based methods
  • Opportunity to build and scale capabilities, not just execute


💡 Why Join Congruence

  • Backed by top-tier investors; >$135M raised
  • High-caliber, multidisciplinary team
  • Competitive compensation + meaningful equity
  • Flexible work environment
  • Mission-driven: delivering therapies to underserved patients
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Senior Scientist, Computational Chemistry • Montreal, QC, Canada

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