Non Animal Model Preclinical Immunology Scientist

Job description:

COMPANY:

Our client is a leading clinical research organization committed to accelerating medical innovation through ethical, high-quality clinical development services. They specialize in preclinical testing of new drug entities for pharma or medical device in advanced therapeutic areas such as immunology, toxicology, pharmacology, and related disorders, with a strong emphasis on NAM Non Animal Models. They are driven by scientific integrity, innovation, and a commitment to humane and responsible research practices. Reports to Immunology Senior Director.

POSITION SUMMARY:

They are seeking a highly motivated and experienced Immunology Scientist with a strong background in non-animal model systems (NAM). The ideal candidate will design, execute, and analyze immunological assays using in vitro and ex vivo human systems, such as primary human cells, organoids, tissue cultures, organ-on-a-chip, and computational models, to support drug discovery and development programs. This is a key scientific role within their translational science team aimed at replacing or reducing animal use while maintaining rigorous, human-relevant data generation.

ROLE AND RESPONSIBILITIES:

• Design and conduct immunological experiments using human primary cells, 3D tissue models, organoids, or other non-animal systems.
• Develop and validate immunoassays (e.g., ELISA, ELISpot, flow cytometry, multiplex cytokine profiling).
• Develop and validate in vitro models to study immune responses, inflammation, autoimmunity, or immuno-oncology.
• Interpret data and generate high-quality reports to support regulatory submissions and sponsor communications.
• Collaborate cross-functionally with clinical, regulatory, and quality teams.
• Stay abreast of the latest advances in non-animal research models and technologies.
• Contribute to the development of standard operating procedures and best practices in immunological testing.
• Support client projects with scientific consultation, protocol development, and presentation of findings.

Qualifications:

REQUIREMENTS:

• B.Sc. in Immunology, Cell Biology, or a related field (or equivalent experience).
• Minimum of 35 years of experience in immunology research, with a focus on non-animal models, preferably in a CRO, biotech, or pharma setting.
• Hands-on expertise with human cell culture systems and immunological assays.
• Experience with alternative human-based models (e.g., organ-on-chip, spheroids, organoids) and familiarity with human immune cell isolation and culture.
• Proficiency in data analysis software (e.g., FlowJo, GraphPad Prism, R, or Python or equivalent).
• Excellent communication skills and ability to work collaboratively in a multidisciplinary environment.

• Experience with creating computational models of immune responses, or systems immunology.
• Familiarity with regulatory requirements and GLP/GCLP standards.
• Prior involvement in client-facing discussions or proposal writing.

Why is This a Great Opportunity:

excellent company with room to grow

cover relocation across Canada or for ex pats

worked with them for > 15 years