Senior Research Associate I, Protein Engineering

Key Responsibilities

• Independently plan, perform, and optimize purification workflows of multispecific antibody therapeutics using AKTA (FPLC) systems, gravity flow columns, and high-throughput plate-based methods
• Perform analytical and biophysical characterization of antibodies and other protein therapeutics for quality control, stability, and developability studies.
• Plan, execute, and evaluate binding studies using SPR, BLI, Kinexa and / or flow cytometry methods, either independently or in collaboration with teammates
• Analyze and review data, draw conclusions, and make recommendations for future investigations
• Initiate and execute novel methods and / or suggest innovative and impactful changes to methods independently or in collaboration with team members
• Participate in cross-departmental collaborative activities and present data at departmental and project team meetings
• Seek to understand ongoing projects through attention to scientific literature, industry publications, and internally generated data and employs this understanding to improve contribution to project goals
• Maintain a clean, organized, and operational lab
• Conduct all activities in accordance with scientific standards, OH&S regulations and established policies and practices
• Actively work to foster an environment of effective and collaborative working relationships across the organization
• Adhere to Zymeworks’ standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic laboratory notebook

Education and Experience

Requires a MSc in a relevant scientific discipline with 3-5 years of relevant work experience, or equivalent combination of education and work experience

Skills and Abilities :

• Good working knowledge and hands-on experience in several of the following areas : Protein purification (e.g. protein A / G / L, IEX, IMAC, and SEC) and familiarity with AKTA (FPLC) systems Protein analytics : PAGE, CE-SDS, HPLC-SEC, cIEF, HIC, ELISA, DSC, DSF, DLS, MALS Binding affinity measurements by SPR, BLI, or Kinexa Additional experience with flow-cytometry, FACS, or other fluorescence cell-based methods would be a plus
• Experience with developability and stability assessments of antibody-based therapeutics would be desirable
• Good organizational and time management skills, work effectively in a fast paced, fast changing environment
• Good critical observation with analytical and problem-solving capabilities
• Good communication skills, including scientific / technical writing and oral skills. Ability to present data effectively at team meetings and inter-departmental meetings

Total Rewards We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth.

We regularly benchmark our compensation against leading biotechnology companies in our geographies. The Canadian base salary range for this full time position is $73, - $, + bonus + equity + benefits.

Our salary ranges are determined by role, level, and location.

The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all Canadian locations.

Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate’s location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience).

Please note that the compensation details listed in role postings reflect the base salary only, and do not include bonus, equity, or benefits. Our team enjoys :

• Industry leading vacation and paid time off
• Excellent health and wellness benefits
• Zymelife health and wellness benefits
• Paid time off to volunteer in your community
• Matching country specific pension savings program
• Employee Share Purchase Program
• Employee Equity Program

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.